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. 2018 Jan 19;13(1):53-59.
doi: 10.1021/acschembio.7b00852. Epub 2017 Dec 4.

Design and Application of a DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu  1 , Alex Shaginian  1 , LaShadric C Grady  1 , Thomas O'Keeffe  1 , Xiangguo E Shi  1 , Christopher P Davie  1 , Graham L Simpson  2 , Jeffrey A Messer  1 , Ghotas Evindar  1 , Robert N Bream  2 , Praew P Thansandote  2 , Naomi R Prentice  2 , Andrew M Mason  2 , Sandeep Pal  2
Affiliations

Design and Application of a DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu et al. ACS Chem Biol. .

Abstract

A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.

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