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. 2017 Dec 22;80(12):3241-3246.
doi: 10.1021/acs.jnatprod.7b00659. Epub 2017 Nov 29.

Oxazole-Containing Diterpenoids from Cell Cultures of Salvia miltiorrhiza and Their Anti-HIV-1 Activities

Dewu Zhang  1 , Jiamei Guo  1 , Min Zhang  1 , Xiao Liu  1 , Mingyu Ba  1 , Xiaoyu Tao  1 , Liyan Yu  1 , Ying Guo  1 , Jungui Dai  1
Affiliations

Oxazole-Containing Diterpenoids from Cell Cultures of Salvia miltiorrhiza and Their Anti-HIV-1 Activities

Dewu Zhang et al. J Nat Prod. .

Abstract

Four new oxazole-containing diterpenoids, salvianans A-D (1-4), along with three known diterpenoids (5-7), were isolated from Salvia miltiorrhiza cell cultures. The structures of the new compounds were elucidated using spectroscopic methods and single-crystal X-ray diffraction. The evaluation for their anti-HIV-1 activities revealed that 2 and 3 displayed inhibitory activities with IC50 values of 0.03 and 1.2 μM, respectively. The time of addition (TOA) assay and long terminal repeat (LTR) luciferase reporter assay results indicated that compound 2 was an HIV-1 transcription inhibitor and might be a lead compound of antiviral agents acting on HIV-1 transcription.

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