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Review
. 2017 May-Jun;92(3):304-311.
doi: 10.1590/abd1806-4841.20176614.

Cutaneous mucormycosis

Ana Daniela Castrejón-Pérez  1 , Esperanza C Welsh  1 , Ivett Miranda  1 , Jorge Ocampo-Candiani  1 , Oliverio Welsh  1
Affiliations
Review

Cutaneous mucormycosis

Ana Daniela Castrejón-Pérez et al. An Bras Dermatol. 2017 May-Jun.

Abstract

Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described. It is an invasive life-threatening disease and in order to improve survival, a prompt diagnosis and multidisciplinary management should be provided. The treatment of choice is amphotericin B, but new azoles, such as posaconazole and isavuconazole, must be considered.

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Conflict of interest statement

Conflict of interest: None

Figures

Figure 1
Figure 1
Cutaneous lesion of mucormycosis
Figure 2
Figure 2
Cutaneous lesion of mucormycosis
Figure 3
Figure 3
Ulceration with necrotic tissue in the eyelid with involvement of the eye
Figure 4
Figure 4
Necrotic eschar and edema of the right eyelid
Figure 5
Figure 5
Ulceration of the soft palate
Figure 6
Figure 6
Skin biopsy that shows hyphae (Hematoxylin & eosin, X40)
See this image and copyright information in PMC

References

    1. Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41:634–653. - PubMed
    1. Skiada A, Pagano L, Groll A, Zimmerli S, Dupont B, Lagrou K, et al. Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the EuropeanConfederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clin Microbiol Infect. 2011;17:1859–1867. - PubMed
    1. Bonifaz A, Vázquez-González D, Tirado-Sánchez A, Ponce-Olivera RM. Cutaneous zygomycosis. Clin Dermatol. 2012;30:413–419. - PubMed
    1. Llata E, Blossom DB, Khoury HJ, Rao CY, Wannemuehler KA, Noble-Wang J, et al. A cluster of mucormycosis infections in hematology patients : challenges in investigation and control of invasive mold infections. DiaDiagn Microbiol Infect Dis. 2011;71:72–80. - PubMed
    1. Rees JR, Pinner RW, Hajjeh RA, Brandt ME, Reingold AL. The epidemiological features of invasive mycotic infections in the San Francisco Bay area, 1992-1993: results of population-based laboratory active surveillance. Clin Infect Dis. 1998;27:1138–1147. - PubMed

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