Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May-Jun;92(3):367-374.
doi: 10.1590/abd1806-4841.20175481.

An overview about oxidation in clinical practice of skin aging

Silas Arandas Monteiro E Silva  1 , Bozena Michniak-Kohn  2 , Gislaine Ricci Leonardi  3
Affiliations
Review

An overview about oxidation in clinical practice of skin aging

Silas Arandas Monteiro E Silva et al. An Bras Dermatol. 2017 May-Jun.

Abstract

Free radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None.

Figures

Figure 1
Figure 1
ROS generation by UVA radiation, producing, in the last instance, the photoaging
Figure 2
Figure 2
Illustration of aspects that could be associate d with oxidative stress and skin aging process, and in vitro /in vivo methodologies that could investigate the antioxidant efficacy
See this image and copyright information in PMC

References

    1. Fluhr JW, Sassning S, Lademann O, Darvin ME, Schanzer S, Kramer A, et al. In vivo skin treatment with tissue-tolerable plasma influences skin physiology and antioxidant profile in human stratum corneum. Exp Dermatol. 2012;21:130–134. - PubMed
    1. Staroňová K, Nielsen JB, Roursgaard M, Knudsen LE. Transport of SiO2 Nanoparticles through Human Skin. Basic Clin Pharmacol Toxicol. 2012;111:142–144. - PubMed
    1. Jennemann R. Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet. 2012;21:586–608. - PubMed
    1. Addor FAZ, Aoki V. Barreira cutânea na dermatite atópica. An Bras Dermatol. 2010;85:184–194. - PubMed
    1. Cheng Y. Protection Effect of Cosmetics on Human Skin Under Simulated Rigorous Environment. Skin Res Technol. 2008;14:45–52. - PubMed

MeSH terms