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Case Reports
. 2017 May-Jun;92(3):404-406.
doi: 10.1590/abd1806-4841.20175561.

Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation

Hatice Duman  1 , Ilteris Oguz Topal  1 , Emek Kocaturk  1 , Kubra Cure  1 , Ilknur Mansuroglu  2
Affiliations
Case Reports

Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation

Hatice Duman et al. An Bras Dermatol. 2017 May-Jun.

Abstract

Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously. We report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid.

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Conflict of interest statement

Conflict of interest: None

Figures

Figure 1
Figure 1
Numerous nonfollicular pustules on the back
Figure 2
Figure 2
Atypical targetoid plaques on the thigh
Figure 3
Figure 3
Subcorneal pustule, spongiosis, leukocytes with polymorphic nuclei, and inflammatory infiltrate on the papillary dermis (Hematoxylin & eosin × 40)
See this image and copyright information in PMC

References

    1. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)-a clinical reaction pattern. J Cutan Pathol. 2001;28:113–119. - PubMed
    1. Paradisi A, Bugatti L, Sisto T, Filosa G, Amerio PL, Capizzi R. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: three cases and a review of the literature. Clin Ther. 2008;30:930–940. - PubMed
    1. Bailey K, McKee D, Wismer J, Shear N. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: first case report in Canada and review of the literature. J Cutan Med Surg. 2013;17:414–418. - PubMed
    1. Posadas SJ, Pichler WJ. Delayed drug hypersensitivity reactions - new concepts. Clin Exp Allergy. 2007;37:989–999. - PubMed
    1. Lateef A, Tan KB, Lau TC. Acute generalized exanthematous pustulosis and toxic epidermal necrolysis induced by hydroxychloroquine. Clin Rheumatol. 2009;28:1449–1452. - PubMed

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