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Case Reports
. 2018 Jan-Feb;21(1):95-99.
doi: 10.1177/1093526617699137. Epub 2017 Mar 20.

Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Jonathan L Metts  1   2 , Sunita I Park  3 , Michael A Briones  1 , Frank G Keller  1
Affiliations
Case Reports

Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Jonathan L Metts et al. Pediatr Dev Pathol. 2018 Jan-Feb.

Abstract

Hemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory disorder that may be encountered as a primary or secondary phenomenon. HLH secondary to lymphoma has been described, more frequently in adults than in children. T-cell/Histiocyte-rich B-cell lymphoma (THRLBCL) is a large B-cell lymphoma that resides in a microenvironment of robust host immune response and has previously been associated with HLH in adults. Here, we describe the first case of HLH secondary to THRLBCL in an adolescent patient.

Keywords: hematopathology; hemophagocytic lymphohistiocytosis; histiocytosis; lymphoma; oncology; pediatric.

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