Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 12;8(19):4141-4154.
doi: 10.7150/jca.22076. eCollection 2017.

Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs

Wenjing Liu  1   2 , Rui Ma  2 , Yuan Yuan  1   3
Affiliations
Review

Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs

Wenjing Liu et al. J Cancer. .

Abstract

Noncoding RNAs play critical roles in regulating protein-coding genes and comprise two major classes: long noncoding RNAs (lncRNAs) and microRNAs (miRNAs). LncRNAs regulate gene expression at transcriptional, post-transcriptional, and epigenetic levels via multiple action modes. LncRNAs can also function as endogenous competitive RNAs for miRNAs and indirectly regulate gene expression post-transcriptionally. By binding to the 3'-untranslated regions (3'-UTR) of target genes, miRNAs post-transcriptionally regulate gene expression. Herein, we conducted a review of post-transcriptional regulation by lncRNAs and miRNAs of genes associated with biological behaviors of gastric cancer.

Keywords: gastric cancer; lncRNAs; miRNAs; ncRNAs; post-transcriptional regulation..

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Post-transcriptional regulation by lncRNAs on the expression of genes related to biological behaviors of gastric cancer. LncRNAs influence post-transcriptional regulation of genes associated with biological behaviors in gastric cancer by altering the process of mRNA degradation and stability or by regulating the expression, degradation, transportation, distribution, and modification of proteins.
Figure 2
Figure 2
Post-transcriptional regulation by miRNAs in the expression of genes related to biological behaviors of gastric cancer. MiRNAs, produced or epigenetically mediated by lncRNAs, silence target genes through interacting with the 3ʹ-UTR, resulting in a series of changes related to biological behaviors in gastric cancer.
Figure 3
Figure 3
The interactions between lncRNAs, miRNAs and mRNAs. A. There are several links between lncRNAs and miRNAs in GC: lncRNAs produce miRNAs through intracellular splicing; lncRNAs silence miRNAs by epigenetically mediation; lncRNAs regulate the expression of transcripts by combining competitively with miRNAs, called ceRNAs mechanism. B. MiRNAs affect post-transcriptional regulation by interacting with the 3ʹ-UTR of mRNAs. C. LncRNAs compete with mRNAs to combine with miRNAs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Fang Y, Fullwood MJ. Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics Proteomics Bioinformatics. 2016;14:42–54. - PMC - PubMed
    1. Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861–74. - PubMed
    1. Bushati N, Cohen SM. microRNA functions. Annu Rev Cell Dev Biol. 2007;23:175–205. - PubMed
    1. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5:522–31. - PubMed
    1. Covarrubias AA, Reyes JL. Post-transcriptional gene regulation of salinity and drought responses by plant microRNAs. Plant Cell Environ. 2010;33:481–9. - PubMed

LinkOut - more resources