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Observational Study
. 2017 Dec;125(6):2113-2122.
doi: 10.1213/ANE.0000000000002586.

Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge

Constance L Monitto  1 , Aaron Hsu  1 , Shuna Gao  1 , Paul T Vozzo  1 , Paul S Park  1 , Deborah Roter  2 , Gayane Yenokyan  3 , Elizabeth D White  1 , Deepa Kattail  1 , Amy E Edgeworth  1 , Kelly J Vasquenza  1 , Sara E Atwater  1 , Joanne E Shay  1 , Jessica A George  1 , Barbara A Vickers  1 , Sabine Kost-Byerly  1 , Benjamin H Lee  1 , Myron Yaster  1
Affiliations
Observational Study

Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge

Constance L Monitto et al. Anesth Analg. 2017 Dec.

Abstract

Background: The epidemic of nonmedical use of prescription opioids has been fueled by the availability of legitimately prescribed unconsumed opioids. The aim of this study was to better understand the contribution of prescriptions written for pediatric patients to this problem by quantifying how much opioid is dispensed and consumed to manage pain after hospital discharge, and whether leftover opioid is appropriately disposed of. Our secondary aim was to explore the association of patient factors with opioid dispensing, consumption, and medication remaining on completion of therapy.

Methods: Using a scripted 10-minute interview, parents of 343 pediatric inpatients (98% postoperative) treated at a university children's hospital were questioned within 48 hours and 10 to 14 days after discharge to determine amount of opioid prescribed and consumed, duration of treatment, and disposition of unconsumed opioid. Multivariable linear regression was used to examine predictors of opioid prescribing, consumption, and doses remaining.

Results: Median number of opioid doses dispensed was 43 (interquartile range, 30-85 doses), and median duration of therapy was 4 days (interquartile range, 1-8 days). Children who underwent orthopedic or Nuss surgery consumed 25.42 (95% confidence interval, 19.16-31.68) more doses than those who underwent other types of surgery (P < .001), and number of doses consumed was positively associated with higher discharge pain scores (P = .032). Overall, 58% (95% confidence interval, 54%-63%) of doses dispensed were not consumed, and the strongest predictor of number of doses remaining was doses dispensed (P < .001). Nineteen percent of families were informed how to dispose of leftover opioid, but only 4% (8 of 211) did so.

Conclusions: Pediatric providers frequently prescribed more opioid than needed to treat pain. This unconsumed opioid may contribute to the epidemic of nonmedical use of prescription opioids. Our findings underscore the need for further research to develop evidence-based opioid prescribing guidelines for physicians treating acute pain in children.

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Conflict of interest statement

Conflict of Interest: Myron Yaster, MD has served as a consultant and on the data safety monitoring board for Purdue Pharma and Endo Pharmaceuticals. With the exception of Dr. Yaster there are no financial disclosures.

Figures

Figure 1
Figure 1. Doses Dispensed and Consumed by Surgical Specialty
Number of opioid doses dispensed and consumed following hospital discharge by surgical specialty/procedure. Data presented as medians and interquartile ranges with outliers depicted as points.
Figure 2
Figure 2. Duration of Opioid Use by Specialty
Duration of opioid therapy (days) reported by families following hospital discharge. Data are stratified by primary service.
See this image and copyright information in PMC

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