Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Oct;76(10):4750-4.
doi: 10.1073/pnas.76.10.4750.

Theory of protein-lipid and protein-protein interactions in bilayer membranes

J C Owicki, H M McConnell

Theory of protein-lipid and protein-protein interactions in bilayer membranes

J C Owicki et al. Proc Natl Acad Sci U S A. 1979 Oct.

Abstract

A model for protein-lipid interactions in bilayer membranes where the proteins are very dilute is extended to higher protein concentration, where appreciable lipid-mediated protein-protein interactions occur. It is found that proteins may change the lipid phase transition temperature and that they weaken the phase transition. There exists a critical protein concentration above which the sharp lipid phase transition is abolished. The model also qualitatively reproduces several experimental observations on the physical behavior of bilayers formed from mixtures of cholesterol and phosphatidylcholines.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5435-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4329-33 - PubMed
    1. FEBS Lett. 1979 Feb 15;98(2):211-23 - PubMed
    1. Biochemistry. 1979 Apr 3;18(7):1156-62 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Apr;75(4):1616-9 - PubMed

Publication types

LinkOut - more resources