Visual Evoked Potentials in Glaucoma and Alzheimer's Disease

Abstract

Visual responses to gratings alternating in contrast have been studied in humans and several mammalian species. Previous evidence from human patients and animal models of neurodegeneration has highlighted the importance to record simultaneously the pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) to investigate retinal and post-retinal sites of neurodegeneration.In view of the increasing importance of research on experimental models of neurodegenerative diseases, we present here the parametric properties of visual evoked responses in animal models of glaucoma and Alzheimer's disease. Glaucoma and Alzheimer's disease (AD) are two distinct multifactorial neurodegenerative and progressive diseases, primarily affecting the elderly.

Keywords: Biomarkers; Neurodegenerations; Pattern electroretinogram (P-ERG); Visual cortical evoked potentials (VEPs); Visual system.