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. 1979 Oct;76(10):4827-31.
doi: 10.1073/pnas.76.10.4827.

Structure of the human G gamma-A gamma-delta-beta-globin gene locus

R Bernards, P F Little, G Annison, R Williamson, R A Flavell

Structure of the human G gamma-A gamma-delta-beta-globin gene locus

R Bernards et al. Proc Natl Acad Sci U S A. 1979 Oct.

Abstract

We have constructed a physical map of the human G gamma-, A gamma-, delta-, and beta-globin genes. The previously described maps of the fetal and adult beta-like globin genes have been linked to one another by identification of a DNA fragment, generated by BamHI, that contains part of each of the A gamma- and delta-globin genes. The map obtained, which spans more than 40 kilobases, shows the following intergene distances: between G gamma and A gamma, 3500 base pairs; between A gamma and delta, 13,500 base pairs; and between delta and beta, 5500 base pairs. All genes are transcribed from the same DNA strand.

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References

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