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Editorial
. 2017 Nov 30;9(11):2241-2242.
doi: 10.18632/aging.101337.

Can oxygen anosmia extend lifespan?

Rachel Abergel  1 , Einav Gross  1
Affiliations
Editorial

Can oxygen anosmia extend lifespan?

Rachel Abergel et al. Aging (Albany NY). .
No abstract available

Keywords: C. elegans; NPR-1; hypoxia; lifespan; oxygen sensing; reactive oxygen species; soluble guanylate cyclase.

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Figures

Figure 1
Figure 1
A schematic illustration presenting a model for the increased lifespan and healthspan of gcy-35(−);npr-1(−) animals. In the absence of gcy-35, the O2-sensing neurons AQR, PQR, and URX are not activated by O2. Our data suggest that GCY-31 and GCY-33 activate a HIF-1-dependent signalling pathway in which neuropeptide and neurotransmitter induce defence responses against bacteria and UV damage in remote tissues. Therefore, although the worm is in a hyperoxic environment, it can benefit from defences activated by hypoxia signalling. The question mark represents our uncertainty about the tissues/cells in which HIF-1 activity is required.
See this image and copyright information in PMC

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