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. 2018 Feb;39(2):252-259.
doi: 10.3174/ajnr.A5441. Epub 2017 Nov 30.

MR Imaging Characteristics Associate with Tumor-Associated Macrophages in Glioblastoma and Provide an Improved Signature for Survival Prognostication

J Zhou  1   2 , M V Reddy  3 , B K J Wilson  3 , D A Blair  4 , A Taha  5   6 , C M Frampton  7 , R A Eiholzer  2 , P Y C Gan  8 , F Ziad  9 , Z Thotathil  10 , S Kirs  6 , N A Hung  2 , J A Royds  2 , T L Slatter  2
Affiliations

MR Imaging Characteristics Associate with Tumor-Associated Macrophages in Glioblastoma and Provide an Improved Signature for Survival Prognostication

J Zhou et al. AJNR Am J Neuroradiol. 2018 Feb.

Abstract

Background and purpose: In glioblastoma, tumor-associated macrophages have tumor-promoting properties. This study determined whether routine MR imaging features could predict molecular subtypes of glioblastoma that differ in the content of tumor-associated macrophages.

Materials and methods: Seven internally derived MR imaging features were assessed in 180 patients, and 25 features from the Visually AcceSAble Rembrandt Images feature set were assessed in 164 patients. Glioblastomas were divided into subtypes based on the telomere maintenance mechanism: alternative lengthening of telomeres positive (ALT+) and negative (ALT-) and the content of tumor-associated macrophages (with [M+] or without [M-] a high content of macrophages). The 3 most frequent subtypes (ALT+/M-, ALT-/M+, and ALT-/M-) were correlated with MR imaging features and clinical parameters. The fourth group (ALT+/M+) did not have enough cases for correlation with MR imaging features.

Results: Tumors with a regular margin and those lacking a fungating margin, an expansive T1/FLAIR ratio, and reduced ependymal extension were more frequent in the subgroup of ALT+/M- (P < .05). Radiologic necrosis, lack of cystic component (by both criteria), and extensive peritumoral edema were more frequent in ALT-/M+ tumors (P < .05). Multivariate testing with a Cox regression analysis found the cystic imaging feature was additive to tumor subtype, and O6-methylguanine methyltransferase (MGMT) status to predict improved patient survival (P < .05).

Conclusions: Glioblastomas with tumor-associated macrophages are associated with routine MR imaging features consistent with these tumors being more aggressive. Inclusion of cystic change with molecular subtypes and MGMT status provided a better estimate of survival.

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Figures

Fig 1.
Fig 1.
Examples of MR imaging features in glioblastoma. A, Tumor classified with a regular (left) or irregular margin (right). B, Tumor classified with a fungating (left) or nonfungating margin (right). C, Tumors classified with a cystic component (left) or noncystic component (right). D, Tumor classified with (left) and without (right) radiologic necrosis. E, Tumor classified with low (limited, left) and high (extensive, right) PTE. F, Tumor classified as being multifocal. G, tumor classified with hemorrhage. Gd indicated gadolinium; C, contrast.
Fig 2.
Fig 2.
The 3 telomere maintenance mechanism subtypes are associated with differences in patient survival. Eighty cases were those used in a previous study, and 100 cases were new to this study.
See this image and copyright information in PMC

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