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Comment
. 2017 Dec 15;36(24):3552-3554.
doi: 10.15252/embj.201798443. Epub 2017 Nov 30.

Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors

Göran Karlsson  1 , Mikael Sigvardsson  1 , Charlotta Böiers  1
Affiliations
Comment

Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors

Göran Karlsson et al. EMBO J. .

Abstract

B‐cell differentiation is one of the most recognized examples of the progressive lineage commitment that is distinctive for stem cell systems. However, the characteristics of the stage just before a cell becomes restricted to the B‐cell lineage are less understood. Using single‐cell RNA sequencing technology, Rolink and colleagues are able to define the cellular heterogeneity at this step and challenge our understanding of developmental trajectories in early B‐lymphoid development (Alberti‐Servera et al, 2017).

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Figures

Figure 1
Figure 1. Single cell RNA sequencing resolves heterogeneity within early lymphoid progenitors
Schematically, B cells are generated in a stepwise manner from hematopoietic stem cells (HSC), and early progenitor with lymphoid and myeloid potential (EPLM) is presumed to be located between common lymphoid progenitors (CLP) and proB cells in the hierarchy. A few selected surface markers are shown for simplicity. The EPLM appears to have lymphoid and myeloid potential when purified by FACS only. However, using single‐cell RNA sequencing Alberti‐Servera et al (2017) reveal heterogeneity in cells’ molecular signatures that divides the EPLM into clusters with distinct lineage programs.
See this image and copyright information in PMC

Comment on

References

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