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Review
. 2018 Jan 2;14(1):234-244.
doi: 10.1080/21645515.2017.1403707. Epub 2017 Dec 15.

Respiratory syncytial virus seasonality and its implications on prevention strategies

Sophie Janet  1 , Jonathan Broad  1 , Matthew D Snape  1
Affiliations
Review

Respiratory syncytial virus seasonality and its implications on prevention strategies

Sophie Janet et al. Hum Vaccin Immunother. .

Abstract

With maternal and infant vaccines against respiratory syncytial virus (RSV) in development, it is timely to consider how the deployment of these vaccines might vary according to local RSV disease seasonality. In temperate regions RSV infection is predictably limited to a period of 3 to 5 months, while in tropical regions disease seasonality is often both more variable and more prolonged. Accordingly, in tropical regions a year-round immunisation schedule for both maternal and infant immunisation might be appropriate. In contrast, in temperate regions the benefit of year-round maternal immunisation would be heavily dependent on the duration of protection this provided, potentially necessitating a strategy directed at children due to be born in the months immediately prior to the RSV season. This review will consider the impact of seasonality on maternal and infant immunisation strategies against RSV, and the potential of an alternative approach of passive immunisation for all infants immediately prior to the RSV season.

Keywords: Respiratory syncytial virus; immunisation; maternal immunisation; public health; seasonality.

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Figures

Figure 1.
Figure 1.
Distribution of RSV peak month by geographic zone (n = 96 locations). The black histogram represents observations while the red curve illustrates the fit of a Gaussian density kernel. Reproduced from: Bloom-Feshbach K, Alonso WJ, Charu V, Tamerius J, Simonsen L, Miller MA, Viboud C. Latitudinal Variations in Seasonal Activity of Influenza and Respiratory Syncytial Virus (RSV): A Global Comparative Review. PLOS ONE 2013;8:e54445.
Figure 2.
Figure 2.
Period of potential protection from RSV infection using different vaccine strategies, using UK as an example of temperate countries assuming RSV season 16th October- 12th March.
Figure 3.
Figure 3.
Period of potential protection from RSV infection using different vaccine strategies, tropical countries.
Figure 4.
Figure 4.
Period of benefit of vaccination strategies on hospital admissions for bronchiolitis in temperate countries (adapted from Parikh ET AL. 2017). Adapted from: Murray J, Bottle A, Sharland M, Modi N, Aylin P, Majeed A, Saxena S, Medicines for Neonates Investigator Group. Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study. PloS one. 2014 Feb 26;9(2):e89186.
Figure 5.
Figure 5.
Suggested maternal RSV immunisation strategy by expected due date (EDD) in United Kingdom (Northern temperate climate), assuming (A) 2 and (B) 4-month period of protection from trans-placental antibodies. Assuming RSV season 16th October- 12th March. Dotted box represents potential targeted immunisation campaign for pregnant women between 16 weeks and 36 weeks gestation in the UK.
See this image and copyright information in PMC

References

    1. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, ET AL.. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375:1545–55. doi:10.1016/S0140-6736(10)60206-1. - DOI - PMC - PubMed
    1. Green CA, Yeates D, Goldacre A, Sande C, Parslow RC, McShane P, Pollard AJ, Goldacre MJ. Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma. Arch Dis Child. 2015;101:1–7. - PMC - PubMed
    1. Chin J, Magoffin RL, Shearer LA, Schieble JH, Lennette EH. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 1969;89:449–63. doi:10.1093/oxfordjournals.aje.a120957. - DOI - PubMed
    1. Fulginiti VA, Eller JJ, Sieber OF, Joyner JW, Minamitani M, Meiklejohn G. Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Am J Epidemiol. 1969;89:435–48. doi:10.1093/oxfordjournals.aje.a120956. - DOI - PubMed
    1. Murphy BR, Alling DW, Snyder MH, Walsh EE, Prince GA, Chanock RM, Hemming VG, Rodriguez WJ, Kim HW, Graham BS. Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol. 1986;24:894–8. - PMC - PubMed

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