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Review
. 2017 Dec 1;9(12):368.
doi: 10.3390/v9120368.

Chikungunya Virus: Pathophysiology, Mechanism, and Modeling

Vaishnavi K Ganesan  1 , Bin Duan  2   3   4 , St Patrick Reid  5
Affiliations
Review

Chikungunya Virus: Pathophysiology, Mechanism, and Modeling

Vaishnavi K Ganesan et al. Viruses. .

Abstract

Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology, pathogenesis, transmission, and mechanism. Diagnosis is largely simplified and based on symptoms, while treatment is supportive rather than curative. Here we present an overview of the disease, the challenges that lie ahead for future research, and what directions current studies are headed towards, with emphasis on improvement of current animal models and potential use of 3D models.

Keywords: 3D organoid; arboviruses; pathogenesis; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CHIKV in vitro and in vivo models. A comparison of the available infection models to study CHIKV pathogenesis, including advantages and disadvantages for each system. Of note, the 3D culture system has not yet been used as an infection model to study CHIKV infection.
See this image and copyright information in PMC

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