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Comment
. 2017 Nov 30;171(6):1252-1253.
doi: 10.1016/j.cell.2017.11.012.

Tumor Evolution: A Problem of Histocompatibility

Natalie I Vokes  1 , Eliezer M Van Allen  2
Affiliations
Comment

Tumor Evolution: A Problem of Histocompatibility

Natalie I Vokes et al. Cell. .

Abstract

In this issue of Cell, two articles show that tumor-specific changes in HLA-mediated antigen presentation affect tumor immunogenicity and may play a role in shaping cancer cell survival.

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Figures

Figure 1.
Figure 1.. The Role of HLA-Mediated Antigen Presentation in Immune Detection and Elimination of Cancer
(A) Mutated cancer proteins are presented as neoantigens via the HLA-containing MHC class I complex to CD8+ T cells, triggering destruction of the transformed cell in a process called immunoediting. (B and C) Mechanisms of loss-of-antigen presentation, leading to cancer cell survival either by incompatible binding between the transformed protein and the individual’s HLA (B) or by loss of HLA heterozygosity (C).
See this image and copyright information in PMC

Comment on

  • Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution.
    McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birkbak NJ, Veeriah S, Van Loo P, Herrero J, Swanton C; TRACERx Consortium. McGranahan N, et al. Cell. 2017 Nov 30;171(6):1259-1271.e11. doi: 10.1016/j.cell.2017.10.001. Epub 2017 Oct 26. Cell. 2017. PMID: 29107330 Free PMC article.

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    1. McGranahan N, Rosenthal R, Hiley CT, Rowan AJ, Watkins TBK, Wilson GA, Birk-bak NJ, Veeriah S, Van Loo P, Herrero J, et al. (2017). Cell 171, this issue, 1259–1271. - PMC - PubMed
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