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Review
. 2017 Oct;31(5):529-536.
doi: 10.1016/j.bpg.2017.09.001. Epub 2017 Sep 6.

Tobacco and alcohol as risk factors for pancreatic cancer

Murray Korc  1 , Christie Y Jeon  2 , Mouad Edderkaoui  3 , Stephen J Pandol  3 , Maxim S Petrov  4 ; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Affiliations
Review

Tobacco and alcohol as risk factors for pancreatic cancer

Murray Korc et al. Best Pract Res Clin Gastroenterol. 2017 Oct.

Abstract

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol.

Keywords: Alcohol; Genetically engineered mouse models; Pancreatic cancer; Population risk; Tobacco.

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Conflict of interest statement

Conflict of interest & financial disclosure

Research reported in this publication was supported by National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award numbers U01DK108323 and U01DK108314. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Figures

Figure 1
Figure 1
Incidence of pancreatic cancer worldwide in 2012 among men (A) and women (B) according to data from the International Agency for Research on Cancer
Figure 2
Figure 2
Tobacco smoking status and risk factor for pancreatic cancer: (A) current smokers versus never smokers, (B) former smokers versus never smokers, and (C) current smokers versus former smokers
Figure 3
Figure 3
Alcohol consumption and risk factor for pancreatic cancer: (A) heavy drinkers versus never drinkers, (B) light drinkers versus never drinkers, and (C) heavy drinkers versus light drinkers
See this image and copyright information in PMC

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