GDF15-From Biomarker to Allostatic Hormone
- PMID: 29195860
- DOI: 10.1016/j.cmet.2017.10.017
GDF15-From Biomarker to Allostatic Hormone
Abstract
With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.Nat Med. 2017 Oct;23(10):1150-1157. doi: 10.1038/nm.4392. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846097
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