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. 2018:1710:173-189.
doi: 10.1007/978-1-4939-7498-6_14.

Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects

Paul Brownbill  1   2 , Neil Sebire  3 , Erin V McGillick  4   5 , Stacey Ellery  4   5 , Padma Murthi  4   5   6
Affiliations

Ex Vivo Dual Perfusion of the Human Placenta: Disease Simulation, Therapeutic Pharmacokinetics and Analysis of Off-Target Effects

Paul Brownbill et al. Methods Mol Biol. 2018.

Abstract

In recent years ex vivo dual perfusion of the human placental lobule is seeing an international renaissance in its application to understanding fetal health and development. Here, we discuss the methods and uses of this technique in the evaluation of (1) vascular function, (2) transplacental clearance, (3) hemodynamic and oxygenation changes associated with pregnancy complications on placental structure and function, and (4) placental toxicology and post-perfusion evaluation of tissue architecture.

Keywords: Fetoplacental; Methods; Off-target effects; Perfusion; Pharmacokinetics; Placenta; Preeclampsia; Structural integrity; Vascular resistance.

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