Deadly combination: Clostridium septicum and colorectal malignancy
- PMID: 29197851
- PMCID: PMC5720338
- DOI: 10.1136/bcr-2017-222759
Deadly combination: Clostridium septicum and colorectal malignancy
Abstract
Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated Clostridiumsepticum is a rare cause of gas gangrene. This case outlines an initial presentation of colonic malignancy as gas gangrene from C.septicum infection.A 69-year-old man presented with abdominal pain, vomiting and constipation. Abdominal X-ray revealed dilated small bowel loops. Lactate was elevated. A diagnosis of small bowel obstruction was made. Subsequent CT revealed caecal thickening and subcutaneous emphysema overlying the left flank. Clinically, he became haemodynamically unstable. Examination revealed crepitus overlying the left flank in keeping with gas gangrene. The patient required immediate surgical debridement. Tissue specimens cultured C.septicum Following a complicated postoperative period, he was transferred to the plastic surgery team for further tissue debridement and reconstruction. A colonoscopy was later performed which was suspicious for malignancy. Colorectal multidisciplinary team discussion is awaited.
Keywords: colon cancer; general surgery; infections; plastic and reconstructive surgery.
© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Conflict of interest statement
Competing interests: None declared.
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References
-
- Perry BN, Floyd WE. Gas gangrene and necrotizing fasciitis in the upper extremity. J Surg Orthop Adv 2004;13:57-68. - PubMed
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