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Review
. 2017 Dec;3(12):812-815.
doi: 10.1016/j.trecan.2017.10.001. Epub 2017 Nov 6.

Spinal Cord Injuries and Nerve Dependence in Prostate Cancer

Alison Rutledge  1 , Phillip Jobling  2 , Marjorie M Walker  3 , Jim W Denham  3 , Hubert Hondermarck  4
Affiliations
Review

Spinal Cord Injuries and Nerve Dependence in Prostate Cancer

Alison Rutledge et al. Trends Cancer. 2017 Dec.

Abstract

Nerves are emerging as drivers of tumorigenesis, as demonstrated in the mouse where denervation suppresses prostate cancer; however, clinical evidence is needed. Patients with spinal cord injuries (SCIs) resulting in functional denervation of the prostate have a lower incidence of prostate cancer. This may constitute a clinical evidence for nerve dependence in human prostate tumorigenesis.

Keywords: cancer; nerve dependence; nerves; prostate; spinal cord injuries.

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