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Comment
. 2018 Jan;93(1):4-6.
doi: 10.1016/j.kint.2017.11.004. Epub 2017 Dec 1.

Using CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation?

Michael J Ross  1 , P Toby Coates  2
Affiliations
Free article
Comment

Using CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation?

Michael J Ross et al. Kidney Int. 2018 Jan.
Free article

Abstract

Xenotransplantation could theoretically provide an unlimited supply of organs for patients living with end-stage kidney disease and other end-stage organ failure, but severe rejection and concerns about possible transmission of zoonotic infections remain important obstacles. In a recent study, investigators used CRISPR-cas9 to generate genetically modified pigs in which all endogenous retroviruses were inactivated. This approach may address one important barrier to the feasibility of clinical trials of xenotransplantation.

Keywords: gene expression; gene therapy; microbiology.

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  • Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
    Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L. Niu D, et al. Science. 2017 Sep 22;357(6357):1303-1307. doi: 10.1126/science.aan4187. Epub 2017 Aug 10. Science. 2017. PMID: 28798043 Free PMC article.

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