Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 4;12(12):CD008380.
doi: 10.1002/14651858.CD008380.pub2.

Invasive versus non-invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders

Fang Luo  1 , Djillali Annane, David Orlikowski, Li He, Mi Yang, Muke Zhou, Guan J Liu
Affiliations

Invasive versus non-invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders

Fang Luo et al. Cochrane Database Syst Rev. .

Abstract

Background: Acute respiratory failure is a common life-threatening complication of acute onset neuromuscular diseases, and may exacerbate chronic hypoventilation in patients with neuromuscular disease or chest wall disorders. Standard management includes oxygen supplementation, physiotherapy, cough assistance, and, whenever needed, antibiotics and intermittent positive pressure ventilation. Non-invasive mechanical ventilation (NIV) via nasal, buccal or full-face devices has become routine practice in many centres.

Objectives: The primary objective of this review was to compare the efficacy of non-invasive ventilation with invasive ventilation in improving short-term survival in acute respiratory failure in people with neuromuscular disease and chest wall disorders. The secondary objectives were to compare the effects of NIV with those of invasive mechanical ventilation on improvement in arterial blood gas after 24 hours and lung function measurements after one month, incidence of barotrauma and ventilator-associated pneumonia, duration of mechanical ventilation, length of stay in the intensive care unit and length of hospital stay.

Search methods: We searched the following databases on 11 September 2017: the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE and Embase. We also searched conference proceedings and clinical trials registries.

Selection criteria: We planned to include randomised or quasi-randomised trials with or without blinding. We planned to include trials performed in children or adults with acute onset neuromuscular diseases or chronic neuromuscular disease or chest wall disorders presenting with acute respiratory failure that compared the benefits and risks of invasive ventilation versus NIV.

Data collection and analysis: Two review authors reviewed searches and independently selected studies for assessment. We planned to follow standard Cochrane methodology for data collection and analysis.

Main results: We did not identify any trials eligible for inclusion in the review.

Authors' conclusions: Acute respiratory failure is a life-threatening complication of acute onset neuromuscular disease and of chronic neuromuscular disease and chest wall disorders. We found no randomised trials on which to elaborate evidence-based practice for the use of non-invasive versus invasive mechanical ventilation. For researchers, there is a need to design and conduct new randomised trials to compare NIV with invasive ventilation in acute neuromuscular respiratory failure. These trials should anticipate variations in treatment responses according to disease condition (acute onset versus acute exacerbation on chronic neuromuscular diseases) and according to the presence or absence of bulbar dysfunction.

PubMed Disclaimer

Conflict of interest statement

FL: none known

DA: none known

DO: DO has received grants from AFRM for a randomised study of non‐invasive ventilation in myotonic dystrophy type 1 and from Phillips for a study of Average Volume Assured Pressure Support (AVAPS) in myotonic dystrophy type 1, and fees from IP Santé à domicile. He has also acted as a medical referee for Foyer ADEP Evry. All the activities mentioned are in the field of care and research conducted in neuromuscular diseases and home ventilation. Outside this work, he received funding from Covidien and from Genzyme to attend the AAN conference in 2012.

LH: none known

MY: none known

MZ: none known

GJL: none known

Figures

1
1
Study flow diagram.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

References to studies excluded from this review

Aggarwal 2009 {published data only}
    1. Aggarwal AN, Agarwal R, Gupta D. Automatic tube compensation as an adjunct for weaning in patients with severe neuroparalytic snake envenomation requiring mechanical ventilation: a pilot randomized study. Respiratory Care 2009;54(12):1697‐702. - PubMed
Chaisson 2006 {published data only}
    1. Chaisson KM, Walsh S, Simmons Z, Vender RL. A clinical pilot study: high frequency chest wall oscillation airway clearance in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 2006;7(2):107‐11. - PubMed
Chatwin 2008 {published data only}
    1. Chatwin M, Nickol AH, Morrell MJ, Polkey MI, Simonds AK. Randomised trial of inpatient versus outpatient initiation of home mechanical ventilation inpatients with nocturnal hypoventilation. Respiratory Medicine 2008;102(11):1528‐35. - PubMed
Fanfulla 2005 {published data only}
    1. Fanfulla F, Delmastro M, Berardinelli A, D’Artavilla Lupo N, Nava S. Effects of different ventilator settings on sleep and inspiratory effort in patients with neuromuscular disease. American Journal of Respiratory and Critical Care Medicine 2005;172:619‐24. - PubMed
Jackson 2001 {published data only}
    1. Jackson CE, Rosenfeld J, Moore DH, Bryan WW, Barohn RJ, Wrench M, et al. A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS/MND patients. Journal of the Neurological Sciences 2001;191(1 ‐ 2):75‐8. - PubMed
Jaye 2009 {published data only}
    1. Jaye J, Chatwin M, Dayer M, Morrell MJ, Simonds AK. Autotitrating versus standard noninvasive ventilation: a randomised crossover trial. European Respiratory Journal 2009;33(3):566‐73. - PubMed
Lechtzin 2010 {published data only}
    1. Lechtzin N, Shade D, Clawson L, Wiener CM. Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosis. Chest 2006;129(5):1322‐9. - PubMed
Martin 2000 {published data only}
    1. Martin TJ, Hovis JD, Costantino JP, Bierman MI, Donahoe MP, Rogers RM, et al. A randomized, prospective evaluation of noninvasive ventilation for acute respiratory failure. American Journal of Respiratory and Critical Care Medicine 2000;161(3 Pt 1):807‐13. - PubMed
Nava 2008 {published data only}
    1. Nava S, Cirio S, Fanfulla F, Carlucci A, Navarra A, Negri A, et al. Comparison of two humidification systems for long‐term noninvasive mechanical ventilation. European Respiratory Journal 2008;32(2):460‐4. - PubMed
Piastra 2006 {published data only}
    1. Piastra M, Antonelli M, Caresta E, Chiaretti A, Polidori G, Conti G. Noninvasive ventilation in childhood acute neuromuscular respiratory failure: a pilot study. Respiration 2006;73(6):791‐8. - PubMed
Reardon 2005 {published data only}
    1. Reardon CC, Christiansen D, Barnett ED, Cabral HJ. Intrapulmonary percussive ventilation vs incentive spirometry for children with neuromuscular disease. Archives of Pediatrics & Adolescent Medicine 2005;159:526‐31. - PubMed
Sancho 2003 {published data only}
    1. Sancho J, Servera E, Vergara P, Marín J. Mechanical insufflation‐exsufflation vs. tracheal suctioning via tracheostomy tubes for patients with amyotrophic lateral sclerosis: a pilot study. American Journal of Physical Medicine & Rehabilitation 2003;82(10):750‐3. - PubMed
Tejeda 1997 {published data only}
    1. Tejeda M, Boix JH, Alvarez F, Balanzá R, Morales M. Comparison of pressure support ventilation and assist‐control ventilation in the treatment of respiratory failure. Chest 1997;111(5):1322‐5. - PubMed
Toussaint 2003 {published data only}
    1. Toussaint M, Win H, Steens M, Soudon P. Effect of intrapulmonary percussive ventilation on mucus clearance in Duchenne muscular dystrophy patients: a preliminary report. Respiratory Care 2003;48(10):940‐7. - PubMed

Additional references

Annane 2014
    1. Annane D, Orlikowski D, Chevret S, Chevrolet JC, Raphael JC. Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders. Cochrane Database of Systematic Reviews 2014, Issue 12. [DOI: 10.1002/14651858.CD001941.pub3] - DOI
Burns 2009
    1. Burns KE, Adhikari NK, Keenan SP, Meade M. Use of non‐invasive ventilation to wean critically ill adults off invasive ventilation: meta‐analysis and systematic review. BMJ 2009;338:b1574. - PMC - PubMed
Carr 2014
    1. Carr AS, Hoeritzauer AI, Kee R, Kinney M, Campbell J, Hutchinson A, et al. Acute neuromuscular respiratory failure: a population‐based study of aetiology and outcome in Northern Ireland. Postgraduate Medical Journal 2014;90(1062):201‐4. - PubMed
Davidson 2016
    1. Davidson AC, Banham S, Elliott M, Kennedy D, Gelder C, Glossop A, et al. BTS Standards of Care Committee Member, British Thoracic Society/Intensive Care Society Acute Hypercapnic Respiratory Failure Guideline Development Group, On behalf of the British Thoracic Society Standards of Care Committee. BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults. Thorax 2016;71(Suppl 2):ii1‐35. - PubMed
Esteban 2008
    1. Esteban A, Ferguson ND, Meade MO, Frutos‐Vivar F, Apezteguia C, Brochard L, et al. VENTILA Group. Evolution of mechanical ventilation in response to clinical research. American Journal of Respiratory and Critical Care Medicine 2008;177(2):170‐7. - PubMed
Garpestad 2007
    1. Garpestad E, Brennan J, Hill NS. Noninvasive ventilation for critical care. Chest 2007;132(2):137. - PubMed
Goligher 2009
    1. Goligher E, Ferguson ND. Mechanical ventilation: epidemiological insights into current practices. Current Opinion in Critical Care 2009;15(1):44‐51. - PubMed
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 updated March 2011. The Cochrane Collaboration. Available from www.cochrane‐handbook.org.
Higgins 2016
    1. Higgins JPT, Lasserson T, Chandler J, Tovey D, Churchill R. Methodological Expectations of Cochrane Intervention Reviews. Cochrane: London 2016.
Hilbert 2001
    1. Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi‐Benissan G, Dupon M, et al. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. New England Journal of Medicine 2001;344:481‐7. - PubMed
Keenan 2004
    1. Keenan SP, Sinuff T, Cook DJ, Hill NS. Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review. Critical Care Medicine 2004;32(12):2516‐23. - PubMed
Leavers 2017
    1. Leavers S, Evans T. Acute respiratory failure. In: Warrell DA, Cox TM, Firth JD editor(s). Oxford Textbook of Medicine. Oxford University Press, 2017. [DOI: 10.1093/med/9780199204854.003.1705_update_004] - DOI
Quon 2008
    1. Quon BS, Gan WQ, Sin DD. Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis. Chest 2008;133(3):756‐66. - PubMed
Radunovic 2017
    1. Radunovic A, Annane D, Rafiq MK, Brassngton R, Mustfa M. Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews 2017, Issue 10. [DOI: 10.1002/14651858.CD004427.pub4] - DOI - PMC - PubMed
Senevirame 2008
    1. Senevirame J, Mandrekar J, Wijdicks EF, Rabinstein AA. Noninvasive ventilation in myasthenic crisis. Archives of Neurology 2008;65(1):54. - PubMed
Serrano 2010
    1. Serrano MC, Rabinstein AA. Causes and outcomes of acute neuromuscular respiratory failure. Archives of Neurology 2010;67(9):1089‐94. - PubMed
Servera 2015
    1. Servera E, Sancho J, Bañuls P, Marín J. Bulbar impairment score predicts noninvasive volume‐cycled ventilation failure during an acute lower respiratory tract infection in ALS. Journal of the Neurological Sciences 2015;358(1‐2):87‐91. - PubMed
Vital 2013
    1. Vital FMR, Ladeira MT, Atallah ÁN. Non‐invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database of Systematic Reviews 2013, Issue 5. [DOI: 10.1002/14651858.CD005351.pub3] - DOI - PubMed
Wijdicks 2017
    1. Wijdicks EFM. The neurology of acutely failing respiratory mechanics. Annals of Neurology 2017;81:485‐94. [PUBMED: 28253561] - PubMed

References to other published versions of this review

Luo 2010
    1. Luo F, Annane D, Orlikowski D, He L, Zhang Y, Yang J, et al. Invasive versus non‐invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders. Cochrane Database of Systematic Reviews 2010, Issue 2. [DOI: 10.1002/14651858.CD008380] - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources