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. 2018 Jan;15(1):57-60.
doi: 10.1038/nmeth.4505. Epub 2017 Dec 4.

Programmable full-adder computations in communicating three-dimensional cell cultures

David Ausländer  1 , Simon Ausländer  1 , Xavier Pierrat  1 , Leon Hellmann  1 , Leila Rachid  1 , Martin Fussenegger  1   2
Affiliations

Programmable full-adder computations in communicating three-dimensional cell cultures

David Ausländer et al. Nat Methods. 2018 Jan.

Abstract

Synthetic biologists have advanced the design of trigger-inducible gene switches and their assembly into input-programmable circuits that enable engineered human cells to perform arithmetic calculations reminiscent of electronic circuits. By designing a versatile plug-and-play molecular-computation platform, we have engineered nine different cell populations with genetic programs, each of which encodes a defined computational instruction. When assembled into 3D cultures, these engineered cell consortia execute programmable multicellular full-adder logics in response to three trigger compounds.

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References

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