Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis
- PMID: 2920020
- PMCID: PMC1135572
- DOI: 10.1042/bj2570293
Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis
Abstract
The concentrations of a small number of mRNAs in the rat ventral prostate increase after castration and then decrease upon androgen treatment. Since the repression of specific gene expression may be important in the regulation of organ growth, we have cloned a cDNA for an androgen-repressed mRNA, the concentration of which increased 17-fold 4 days after castration, and this increase was reversed rapidly by androgen treatment. By sequence analysis the androgen-repressed mRNA was identified as that coding for sulphated glycoprotein 2.
Similar articles
-
Regional and cellular distribution within the rat prostate of two mRNA species undergoing opposite regulation by androgens.J Endocrinol. 1992 Mar;132(3):361-7. doi: 10.1677/joe.0.1320361. J Endocrinol. 1992. PMID: 1564420
-
Diverse secretory patterns of clusterin by epididymis and prostate/seminal vesicles undergoing cell regression after orchiectomy.Endocrinology. 1990 Jun;126(6):2989-97. doi: 10.1210/endo-126-6-2989. Endocrinology. 1990. PMID: 2351105
-
Castration induces apoptosis in the ventral prostate but not in an androgen-sensitive prostatic adenocarcinoma in the rat.Cancer Res. 1994 Jul 1;54(13):3594-601. Cancer Res. 1994. PMID: 8012987
-
Differential effect of 5 alpha-reductase inhibition and castration on androgen-regulated gene expression in rat prostate.Mol Endocrinol. 1991 Jul;5(7):1023-9. doi: 10.1210/mend-5-7-1023. Mol Endocrinol. 1991. PMID: 1719382
-
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate.Biochem Biophys Res Commun. 1987 Aug 31;147(1):196-203. doi: 10.1016/s0006-291x(87)80106-7. Biochem Biophys Res Commun. 1987. PMID: 3632663
Cited by
-
Clusterin: Review of research progress and looking ahead to direction in hepatocellular carcinoma.World J Gastroenterol. 2015 Jul 21;21(27):8262-70. doi: 10.3748/wjg.v21.i27.8262. World J Gastroenterol. 2015. PMID: 26217078 Free PMC article. Review.
-
Clusterin silencing inhibits proliferation and reduces invasion in human laryngeal squamous carcinoma cells.World J Surg Oncol. 2014 Apr 26;12:124. doi: 10.1186/1477-7819-12-124. World J Surg Oncol. 2014. PMID: 24767179 Free PMC article.
-
mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.J Cell Physiol. 2012 May;227(5):1805-13. doi: 10.1002/jcp.22904. J Cell Physiol. 2012. PMID: 21732348 Free PMC article.
-
A signaling network in phenylephrine-induced benign prostatic hyperplasia.Endocrinology. 2009 Aug;150(8):3576-83. doi: 10.1210/en.2008-1782. Epub 2009 May 14. Endocrinology. 2009. PMID: 19443575 Free PMC article.
-
DNA and cell death.Cytotechnology. 1991 Feb;5(Suppl 1):74-7. doi: 10.1007/BF00736814. Cytotechnology. 1991. PMID: 22358960
References
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases