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. 2017 Nov 23:12:31.
doi: 10.1186/s12995-017-0177-2. eCollection 2017.

Risk of lymphoma subtypes by occupational exposure in Southern Italy

Giovanni Maria Ferri  1   2 , Giorgina Specchia  3 , Patrizio Mazza  4 , Giuseppe Ingravallo #  5 , Graziana Intranuovo  1 , Chiara Monica Guastadisegno #  1 , Maria Luisa Congedo #  1 , Gianfranco Lagioia #  1 , Maria Cristina Loparco #  1 , Annamaria Giordano #  3 , Tommasina Perrone #  3 , Francesco Gaudio #  3 , Caterina Spinosa #  4 , Carla Minoia #  4 , Lucia D'Onghia #  4 , Michela Strusi #  4 , Vincenzo Corrado #  1 , Domenica Cavone #  1 , Luigi Vimercati #  1 , Nunzia Schiavulli #  1 , Pierluigi Cocco  6
Affiliations

Risk of lymphoma subtypes by occupational exposure in Southern Italy

Giovanni Maria Ferri et al. J Occup Med Toxicol. .

Erratum in

  • Correction to: Risk of lymphoma subtypes by occupational exposure in southern Italy.
    Ferri GM, Specchia G, Mazza P, Ingravallo G, Intranuovo G, Guastadisegno CM, Congedo ML, Lagioia G, Loparco MC, Giordano A, Perrone T, Gaudio F, Spinosa C, Minoia C, D'Onghia L, Strusi M, Corrado V, Cavone D, Vimercati L, Schiavulli N, Cocco P. Ferri GM, et al. J Occup Med Toxicol. 2020 Mar 20;15:6. doi: 10.1186/s12995-020-00256-1. eCollection 2020. J Occup Med Toxicol. 2020. PMID: 32206079 Free PMC article.

Abstract

Background: Occupational exposure is known to play a role in the aetiology of lymphomas. The aim of the present work was to explore the occupational risk of the major B-cell lymphoma subtypes using a case-control study design.

Methods: From 2009 to 2014, we recruited 158 lymphoma cases and 76 controls in the provinces of Bari and Taranto (Apulia, Southern Italy). A retrospective assessment of occupational exposure based on complete work histories and the Carcinogen Exposure (CAREX) job-exposure matrix was performed.

Results: After adjusting for major confounding factors, farmers showed an increased risk of diffuse large B-cell lymphoma (DLBCL) [odds ratio (OR) = 10.9 (2.3-51.6)] and multiple myeloma (MM) [OR = 16.5 (1.4-195.7)]; exposure to the fungicide Captafol was significantly associated with risk of non-Hodgkin lymphoma (NHL) [OR = 2.6 (1.1-8.2)], particularly with the risk of DLBCL [OR = 5.3 (1.6-17.3)].

Conclusions: Agricultural activity seems to be a risk factor for developing lymphoma subtypes, particularly DLBCL, in the provinces of Bari and Taranto (Apulia Region, Southern Italy). Exposure to the pesticides Captafol, Paraquat and Radon might be implicated.

Trial registration: Protocol number UNIBA 2207WEJLZB_004 registered 22/09/2008.

Keywords: B-cell lymphoma subtypes; CAREX matrix; Case–control study; Lymphomas; Occupational exposure; Pesticides.

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Conflict of interest statement

Authors’ information

All the authors are interested in the development of the scientific fields related to this work, including cancer epidemiology and haematology.

Ethics approval and consent to participate

- Regione Puglia.

Azienda Ospedaliera “Ospedale Policlinico Consorziale” di Bari.

COMITATO ETICO INDIPENDENTE LOCALE.

Prot.n. 1193/C.E. 07/10/2008.

- Regione Puglia.

Azienda Ospedaliera “Ospedale Policlinico Consorziale” di Bari.

COMITATO ETICO INDIPENDENTE LOCALE.

Prot.n. 25/C.E. 09/01/2012.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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