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. 2017 Oct 6;7(11):e00850.
doi: 10.1002/brb3.850. eCollection 2017 Nov.

Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use

Rohit J Lodhi  1 , Yabing Wang  1 , David Rossolatos  1 , Georgina MacIntyre  2 , Alexandra Bowker  3 , Candice Crocker  4 , Hongyan Ren  1 , Aleksandra Dimitrijevic  2 , Darren A Bugbee  2 , Alexandra Loverock  3 , Brett Majeau  3 , Sudhakar Sivapalan  1 , Virginia M Newton  3 , Philip Tibbo  4   5 , Scot E Purdon  1   3   6 , Katherine J Aitchison  1   6   7
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Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use

Rohit J Lodhi et al. Brain Behav. .

Erratum in

Abstract

Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.

Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire. DNA was extracted from saliva and genotyping of the COMT Val158Met polymorphism was done by SNaPshot and TaqMan assays. Kaplan-Meier analysis results are reported.

Results: In those who had used cannabis before 20 years of age, rs4680 had a trend level effect on AoP (median AoP: Val/Val < Val/Met < Met/Met 19.37, 20.95, 21.24 years, respectively; log-rank test p = .051).

Conclusion: Our data are indicative of the need to further investigate the association between the COMT rs4680 variant and AoP in the context of adolescent cannabis use.

Keywords: cannabis; catechol‐O‐methyltransferase; genes; psychotic disorders; sex.

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Figure 1
Figure 1
Time to age of diagnosis of psychosis by gender and COMT Val158Met genotype
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