Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Jul-Dec;5(2):115-117.
doi: 10.5005/jp-journals-10018-1148. Epub 2016 Jul 9.

A Case Report of Ulcerative Colitis Induced by Therapy of Colorectal Carcinoma

Tuncer Temel  1 , Safak Meric Ozgenel  1 , Funda Canaz  2 , Deniz Arik  2 , Salih Tokmak  1 , Aysegul Harmanci Ozakyol  2
Affiliations
Case Reports

A Case Report of Ulcerative Colitis Induced by Therapy of Colorectal Carcinoma

Tuncer Temel et al. Euroasian J Hepatogastroenterol. 2015 Jul-Dec.

Abstract

Although patients with ulcerative colitis have an increased risk for colon cancer which is associated with disease activity, location of involvement or the accompanying primary sclerosing cholangitis, ulcerative colitis induced by resections for colorectal carcinoma or chemotherapy drugs are very rare as case presentations in the literature. Fifty-nine year-old female patient with the diagnosis of sigmoid colon carcinoma have been developed ulcerative colitis 2 months after low anterior resection and oral capecitabine treatment. Development of colitis after colon cancer may be associated with some causes as mutual genetic factors that take part at the pathophysiological mechanisms liable from occurrence of ulcerative colitis and colorectal carcinoma, chemotherapy agents, perioperative stress and underlying silent ulcerative colitis. It is unclear which role is certain. Increasing reports like this case will be useful in resolving this issue.

How to cite this article: Temel T, Ozgenel SM, Canaz F, Arik D, Tokmak S, Ozakyol AH. A Case Report of Ulcerative Colitis Induced by Therapy of Colorectal Carcinoma. Euroasian J Hepato-Gastroenterol 2015;5(2):115-117.

Keywords: Capecitabine; Colectomy; Colorectal carcinoma; Ulcerative colitis..

PubMed Disclaimer

Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Fig. 1:
Fig. 1:
Tumoral mass in scirrhous feature detected on sigmoid colon
Fig. 2:
Fig. 2:
Pathological finding of the biopsy specimens obtained from the mass which was reported as colorectal carcinoma
Fig. 3:
Fig. 3:
Hyperemic, edematous, spontaneous fragile and erosive mucosa of the colon
Fig. 4:
Fig. 4:
Chronic active colitis with distinct inflammation, moderate activation, crypt abscess, distortion and destruction
See this image and copyright information in PMC

References

    1. Herszényi L, Barabás L, Miheller P, Tulassay Z. Colorectal cancer in patients with inflammatory bowel disease: the true impact of the risk. Dig Dis. 2015;33(1):52–57. - PubMed
    1. Sartor RB. Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006;3(7):390–407. - PubMed
    1. Takakura M1, Mochizuki N, Yamauchi K, Suzuki S, Konishi H, Takeo Y, Suzuki M, Tanaka M. Acute onset of ulcerative colitis following an operation for sigmoid colon cancer. J Gastroenterol. 2006;41(1):77–82. - PubMed
    1. Lim AG, Langmead FL, Feakins RM, Rampton DS. Diversion colitis: a trigger for ulcerative colitis in the in-stream colon? Gut. 1999;44(2):279–282. - PMC - PubMed
    1. Katsanos KH, Christodoulou D, Siozopoulou V, Eufimia B, Bali C, Fatouros M, Mitsi V, Tsianos EV. Silent ulcerative colitis adjacent to a regular sigmoid adenocarcinoma. Eur J Gastroenterol Hepatol. 2011;23(10):957–960. - PubMed

Publication types

LinkOut - more resources