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. 2018 Jan 4;217(2):257-262.
doi: 10.1093/infdis/jix512.

Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection

Shokouh Makvandi-Nejad  1 , Henry Laurenson-Schafer  1 , LiLi Wang  1 , Dannielle Wellington  1 , Yan Zhao  2   3 , Boquan Jin  4 , Ling Qin  2   3 , Kerry Kite  1 , Hooman K Moghadam  5 , Chaojun Song  4 , Kevin Clark  6 , Philip Hublitz  7 , Alain R Townsend  2 , Hao Wu  3 , Andrew J McMichael  1   2 , YongHong Zhang  2   3 , Tao Dong  1   2   3
Affiliations

Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection

Shokouh Makvandi-Nejad et al. J Infect Dis. .

Abstract

Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. Full-length IFITM3 protein can be detected in all genotypes.

Keywords: IFITM3; influenza A virus; rs12252.

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