Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable

Abstract

Numerous epidemiological studies suggest that air pollutants cause a decline in the quality of human spermatozoa and thus a reduction in fertility. However, the exact cause of infertility remains unknown. Air pollution gases, such as NH₃ and H₂S are either free or bound to airborne particular materials (PM) and are abundant and reactive. The aim of this current investigation was to explore the impacts of NH₃ and/or H₂S on male fertility and the underlying mechanisms. Male mouse exposed to H₂S and/or NH₃ and after two generations were used to evaluate the impacts on fertility. The fertility, and spermatozoa quality parameters and proteins involved in spermatogenesis were investigated. Our current investigation demonstrates: i) H₂S and/or NH₃ decrease male fertility by 20-30%, reduce the spermatozoa concentration about 20-40%, decrease 10-20%, increase around 30%; ii) the reduction in male fertility by H₂S and/or NH₃ can be inheritable; iii) H₂S and/or NH₃ can diminish male fertility through the disruption of spermatogenesis without affecting other body parameters such as body weight and organ index. One component of air pollutants, for example NH₃, does not have a severe impact; however, two or more pollutants such as H₂S and NH₃ combined can cause serious health problems, especially with regard to male fertility. We suggest that greater attention should be paid to these air pollutants to improve human health and fertility.

Keywords: H(2)S; Heritance; Male fertility; NH(3); Spermatogenesis.