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Comment
. 2018 Jan;28(1):3-5.
doi: 10.1016/j.tcb.2017.11.003. Epub 2017 Dec 1.

Vms1: A Cytosolic CAT-Tailing Antagonist to Protect Mitochondria

Stefan G Kreft  1 , Elke Deuerling  2
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Comment

Vms1: A Cytosolic CAT-Tailing Antagonist to Protect Mitochondria

Stefan G Kreft et al. Trends Cell Biol. 2018 Jan.

Abstract

In eukaryotes, a cytosolic ribosome quality control complex recycles erroneously stalled ribosomes and modifies faulty nascent chains by ubiquitination and by C-terminal Ala- and Thr-extension (CAT-tailing). Reported recently in Cell, Izawa et al. identify cytosolic Vms1 (VCP/Cdc48-associated mitochondrial stress-responsive 1) as an inhibitor of CAT-tailing, which prevents mitochondrial dysfunction caused by imported CAT-tailed polypeptides.

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