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. 2017 Dec;8(4):540-547.
doi: 10.1007/s13193-017-0680-z. Epub 2017 Jul 21.

Ovarian Cancer in Young Women

Eileen Lalrinpuii  1 , Pallipuram Seshadrinathan Bhageerathy  1 , Ajit Sebastian  1 , Lakshmanan Jeyaseelan  2 , VinothaThomas  1 , Anitha Thomas  1 , Rachel Chandy  1 , Abraham Peedicayil  1
Affiliations

Ovarian Cancer in Young Women

Eileen Lalrinpuii et al. Indian J Surg Oncol. 2017 Dec.

Abstract

It is not clear how often epithelial tumours affect young women. This study aimed to evaluate the clinico-pathological pattern and survival outcome of women, 40 years and younger, with cancer ovary. Women 40 years and younger, operated between 2008 and 2012 for ovarian cancer, were retrospectively recruited and followed up. The study design was descriptive as well as a survival analysis. A hybrid of retrospective and prospective cohort design was used for risk factor analysis. Of the 115 women less than 40 years being operated for probable ovarian cancer, 22 were excluded for various reasons. Demographic details, clinical presentations, histopathological features, treatments and survival outcomes were studied. The primary outcomes looked for were death and recurrence. Secondary outcomes were complications of treatment and fertility. The predominant histology in the study population was epithelial tumour (70%), and serous adenocarcinoma was the commonest tumour type. The overall survival rate was 87%, and progression free survival was 63%. Time to death and recurrence were dependent on stage of disease, histology of tumour, primary treatment and residual disease at surgery. In multivariate analysis, the hazard ratio for recurrence in advanced stages was 12.6 (95% CI 3.5 to 45.5; p < 0.001) as compared to early stage disease. Epithelial ovarian cancers are common in young women. Death and recurrence are more likely in women with epithelial cancers, advanced stage disease and in those with residual tumour at cytoreductive surgery.

Keywords: Ovarian cancer; Young women.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Fig. 1
Fig. 1
Flow chart showing patient recruitment
Fig. 2
Fig. 2
Overall survival (a) and disease-free survival (b) by tumour histology
Fig. 3
Fig. 3
Overall survival (a) and disease-free survival (b) by stage of disease
Fig. 4
Fig. 4
Overall survival (a) and disease-free survival (b) by primary treatment
Fig. 5
Fig. 5
Overall survival (a) and disease-free survival (b) based on optimal vs suboptimal debulking
See this image and copyright information in PMC

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