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. 2017 Oct-Dec;8(4):595-600.
doi: 10.4103/jnrp.jnrp_270_17.

Cranioplasty Using Autoclaved Autologous Skull Bone Flaps Preserved at Ambient Temperature

Dominic Anto  1 , Raju Paul Manjooran  1 , Rajeev Aravindakshan  2 , Kumar Lakshman  1 , Raymond Morris  1
Affiliations

Cranioplasty Using Autoclaved Autologous Skull Bone Flaps Preserved at Ambient Temperature

Dominic Anto et al. J Neurosci Rural Pract. 2017 Oct-Dec.

Abstract

Context: Decompressive craniectomy followed by cranioplasty (CP) uses autologous craniectomy flaps or synthetic materials like titanium. Sterilization and preservation methods for the autologous bone flaps continue to be the surgeon's choice.

Aim: This study aimed to assess the short-term as well as long-term clinical outcomes of CP using autoclaved autologous bone grafts.

Settings and design: This retrospective observational study was performed on patients admitted in a tertiary care teaching neurosurgery department.

Patients and methods: Seventy-two patients who underwent CP with autoclaved autologous skull flaps preserved under ambient conditions with strict aseptic precautions were included in the study.

Statistical analysis used: Frequencies and percentages of the various characteristics before and after the surgery were tabulated. Continuous variables were summarized as means and standard deviations.

Results: The primary CP had a satisfactory clinical outcome in 62 cases (86.11%). Osteomyelitis was observed in four patients (5.56%) nearly 2 months after the surgery. Radiologically significant bone resorption was noted in a single patient (1.39%) after 1 year. Five patients (6.94%) developed bone fragmentation or fracture, and the mean time taken for this was about 36 months. In all these ten cases, secondary CP was successfully done using a prefabricated, patient-specific titanium mesh.

Conclusions: The efficacy and safety of the studied craniectomy flaps used for cranial reconstruction showed a good patient outcome. Further retrospective studies with larger cohorts and prospective case-control studies are essential so as to issue standard guidelines for sterilization and preservation of autologous bone flaps.

Keywords: Ambient temperature; autoclaving; autologous skull bone flap; cranioplasty; storage.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Indications for decompressive craniectomy
Figure 2
Figure 2
(a) Bone flap resorption along the edges of the graft. (b) Bone flap fragmentation/fracture
See this image and copyright information in PMC

References

    1. Zhang J, Peng F, Liu Z, Luan J, Liu X, Fei C, et al. Cranioplasty with autogenous bone flaps cryopreserved in povidone iodine: A long-term follow-up study? J Neurosurg. 2017:1–8. doi: 10.3171/2016.8.JNS16204. [Epub ahead of print] - PubMed
    1. Rocque BG, Amancherla K, Lew SM, Lam S. Outcomes of cranioplasty following decompressive craniectomy in the pediatric population. J Neurosurg Pediatr. 2013;12:120–5. - PubMed
    1. Lee SH, Yoo CJ, Lee U, Park CW, Lee SG, Kim WK, et al. Resorption of autogenous bone graft in cranioplasty: Resorption and reintegration failure. Korean J Neurotrauma. 2014;10:10–4. - PMC - PubMed
    1. Piedra MP, Thompson EM, Selden NR, Ragel BT, Guillaume DJ. Optimal timing of autologous cranioplasty after decompressive craniectomy in children. J Neurosurg Pediatr. 2012;10:268–72. - PubMed
    1. Brommeland T, Rydning PN, Pripp AH, Helseth E. Cranioplasty complications and risk factors associated with bone flap resorption. Scand J Trauma Resusc Emerg Med. 2015;23:75. - PMC - PubMed

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