Chromosome 15 Duplication and Attention-Deficit Hyperactivity Disorder
- PMID: 29204034
- PMCID: PMC5709897
- DOI: 10.4103/jnrp.jnrp_316_17
Chromosome 15 Duplication and Attention-Deficit Hyperactivity Disorder
Abstract
Chromosome 15 duplication has been associated with a number of psychiatric illnesses including psychosis and autism. However, literature on association with attention-deficit hyperactivity disorder (ADHD) is scant. This case report describes a patient with chromosome 15 duplication diagnosed with ADHD in our neurodevelopmental clinic. The possible biological underpinnings are discussed along with possible challenges in diagnosis and management. The need for better understanding ADHD as a behavioral phenotype in such cases along with need for tailored management strategies is emphasized.
Keywords: Attention-deficit hyperactivity disorder; chromosome 15 duplication; genetics.
Conflict of interest statement
There are no conflicts of interest.
Similar articles
-
Inattention and hyperactivity/impulsivity among children with attention-deficit/hyperactivity-disorder, autism spectrum disorder, and intellectual disability.Res Dev Disabil. 2017 Nov;70:175-184. doi: 10.1016/j.ridd.2017.09.009. Epub 2017 Sep 26. Res Dev Disabil. 2017. PMID: 28957735
-
Co-morbidity in Attention-Deficit Hyperactivity Disorder: A Clinical Study from India.East Asian Arch Psychiatry. 2016 Dec;26(4):148-53. East Asian Arch Psychiatry. 2016. PMID: 28053283
-
SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder.J Child Psychol Psychiatry. 2017 Jul;58(7):798-809. doi: 10.1111/jcpp.12702. Epub 2017 Feb 22. J Child Psychol Psychiatry. 2017. PMID: 28224622
-
Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Preschool-Aged Children.J Child Adolesc Psychopharmacol. 2018 Nov;28(9):606-614. doi: 10.1089/cap.2018.0057. Epub 2018 Nov 2. J Child Adolesc Psychopharmacol. 2018. PMID: 30388032 Review.
-
Molecular mechanisms underlying neurodevelopmental disorders, ADHD and autism.Rom J Morphol Embryol. 2016;57(2):361-6. Rom J Morphol Embryol. 2016. PMID: 27516006 Review.
Cited by
-
Commentary.J Neurosci Rural Pract. 2017 Oct-Dec;8(4):662-663. doi: 10.4103/jnrp.jnrp_408_17. J Neurosci Rural Pract. 2017. PMID: 29204035 Free PMC article. No abstract available.
References
-
- Bolton PF, Dennis NR, Browne CE, Thomas NS, Veltman MW, Thompson RJ, et al. The phenotypic manifestations of interstitial duplications of proximal 15q with special reference to the autistic spectrum disorders. Am J Med Genet. 2001;105:675–85. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources