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Observational Study
. 2017 Nov 14;23(42):7618-7625.
doi: 10.3748/wjg.v23.i42.7618.

Right- and left-sided colorectal cancers respond differently to traditional Chinese medicine

Shan-Shan Liu  1 , Qi Shi  1 , Hong-Jia Li  1 , Wei Yang  1 , Su-Su Han  1 , Shao-Qi Zong  1 , Wen Li  1 , Feng-Gang Hou  2
Affiliations
Observational Study

Right- and left-sided colorectal cancers respond differently to traditional Chinese medicine

Shan-Shan Liu et al. World J Gastroenterol. .

Abstract

Aim: To explore the differences in the responses of left-sided colorectal cancer (LSCRC) and right-sided colon cancer (RSCC) to traditional Chinese medicine (TCM).

Methods: Patients with postoperative stage I-III colorectal cancer (CRC) were enrolled and divided into the LSCRC with or without TCM and RSCC with or without TCM groups depending on the primary tumor side and TCM administration. Patients in the TCM group were given TCM for at least 6 mo. Our research adopted disease-free survival (DFS) as the primary endpoint. We applied a Cox proportional hazards regression model for the multivariate factor analysis using Stata 12.0 and SPSS 22.0 software for data analysis.

Results: Of the 817 patients included in our study, 617 had LSCRC (TCM group, n = 404; Non-TCM group, n = 213), and 200 had RSCC (TCM group, n = 132; Non-TCM group, n = 68). The 6-year DFS for patients with LSCRC was 56.95% in the TCM group and 41.50% in the Non-TCM group (P = 0.000). For patients with RSCC, the 6-year DFS was 52.92% in the TCM group and 37.19% in the Non-TCM group (P = 0.003). Differences between LSCRC and RSCC were not statistically significant regardless of TCM ingestion.

Conclusion: Patients with either LSCRC or RSCC and who took TCM experienced longer DFS; furthermore, patients with RSCC benefited more from TCM in DFS.

Keywords: Colorectal cancer; Disease-free survival; Left-sided; Right-sided; Traditional Chinese medicine.

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Conflict of interest statement

Conflict-of-interest statement: All authors have declared no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of patient selection and grouping.
Figure 2
Figure 2
Kaplan-Meier disease-free survival curves for all patients.
Figure 3
Figure 3
Kaplan-Meier disease-free survival curves for patients with stage I disease.
Figure 4
Figure 4
Kaplan-Meier disease-free survival curves for patients with stage II disease.
Figure 5
Figure 5
Kaplan-Meier disease-free survival curves for patients with stage III disease.
See this image and copyright information in PMC

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