Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017:2017:7467962.
doi: 10.1155/2017/7467962. Epub 2017 Oct 24.

Dietary Polyphenols in the Prevention of Stroke

A Tressera-Rimbau  1   2 , S Arranz  3 , M Eder  4 , A Vallverdú-Queralt  4
Affiliations
Review

Dietary Polyphenols in the Prevention of Stroke

A Tressera-Rimbau et al. Oxid Med Cell Longev. 2017.

Abstract

Polyphenols have an important protective role against a number of diseases, such as atherosclerosis, brain dysfunction, stroke, cardiovascular diseases, and cancer. Cardiovascular diseases are the number one cause of death worldwide: more people die annually from cardiovascular diseases than from any other cause. The most important behavioural risk factors of heart disease and stroke are unhealthy diet, physical inactivity, tobacco use, and excess alcohol intake. The dietary consumption of polyphenols has shown to be inversely associated with morbidity and mortality by cardio- and cerebrovascular diseases. It is well-known that the protective effects of polyphenols in vivo depend on the grade how they are extracted from food and on their intestinal absorption, metabolism, and biological action with target tissues. The aim of this review was to summarise the relation between polyphenols of different plant sources and stroke in human intervention studies, animal models, and in vitro studies.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Molecular signaling pathways and molecular risk factors modulated by polyphenols in neurological disorders.
See this image and copyright information in PMC

References

    1. Del Rio D., Rodriguez-Mateos A., Spencer J. P. E., Tognolini M., Borges G., Crozier A. Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects against Chronic Diseases. Vol. 18. 140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801 USA: Antioxidants & Redox Signaling; 2013. - PMC - PubMed
    1. Lamuela-Raventós R. M., Vallverdú-Queralt A., Jáuregui O., Martínez-Huélamo M., Quifer-Rada P. Improved characterization of polyphenols using liquid chromatography. Polyphenols in Plants. 2014;14:261–292. doi: 10.1016/B978-0-12-397934-6.00014-0. - DOI
    1. Crozier A., Jaganath I. B., Clifford M. N. Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports. 2009;26(8):1001–1043. doi: 10.1039/b802662a. - DOI - PubMed
    1. Vallverdú-Queralt A., Boix N., Piqué E., et al. Identification of phenolic compounds in red wine extract samples and zebrafish embryos by HPLC-ESI-LTQ-Orbitrap-MS. Food Chemistry. 2015;181:146–151. doi: 10.1016/j.foodchem.2015.02.098. - DOI - PubMed
    1. Frei B., Higdon J. V. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. The Journal of Nutrition. 2003;133(10):3275S–3284S. - PubMed

MeSH terms

LinkOut - more resources