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. 2017 Oct 28:19:18-20.
doi: 10.1016/j.mmcr.2017.10.001. eCollection 2018 Mar.

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

Rodrigo Vettorato  1   2 , Daiane Heidrich  1 , Fernanda Fraga  3 , Amanda Carvalho Ribeiro  4 , Danielle Machado Pagani  3   4 , Carina Timotheo  3   4 , Tais Guarienti Amaro  2 , Gerson Vettorato  2 , Maria Lúcia Scroferneker  1   3
Affiliations

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

Rodrigo Vettorato et al. Med Mycol Case Rep. .

Abstract

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months.

Keywords: Antifungal susceptibility; Itraconazole; Senso stricto; Sporothrix schenckii; Sporotrichosis; Terbinafine.

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Figures

Fig. 1
Fig. 1
Lesions of sporotrichosis, containing nodule following the ascending lymphatic path (A) with verrucous plaque in right hand, initial site of infection (B); After four months of treatment with terbinafine (500 mg/day), showing scars of the lesions (C, D).
See this image and copyright information in PMC

References

    1. Suzuki R., Yikelamu A., Tanaka R., Igawa K., Yolozeki H., Yaguchi T. Studies in phylogeny, development of rapid identification methods, antifungal susceptibility, and growth rates of clinical strains of Sporothrix schenckii complex in Japan. Med. Mycol. J. 2016:E47–E57. - PubMed
    1. Bonifaz A. 4th ed. Mcgraw-Hill Interamericana; México: 2012. Micología Médica Básica; pp. 214–230.
    1. Chakrabarti A., Bonifaz A., Gutierrez-Galhardo M.C., Mochizuki T., Li S. Global epidemiology of sporotrichosis. Med. Mycol. 2015;53:3–14. - PubMed
    1. JMR Yuil, Candiani J.O. Página; Buenos Aires: 2016. Manual de Dermatologia Infecciosa; pp. 360–367.
    1. Lacaz . 9th ed. Sarvier; São Paulo: 2002. Tratado de Micologia Médica Lacaz.

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