Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017:2017:4754701.
doi: 10.1155/2017/4754701. Epub 2017 Oct 24.

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Adriana E Bulboacă  1 , Sorana D Bolboacă  2 , Ioana C Stănescu  3 , Carmen A Sfrângeu  1 , Angelo C Bulboacă  3
Affiliations

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Adriana E Bulboacă et al. Biomed Res Int. 2017.

Abstract

Objective: Our study aimed to investigate the analgesic and antioxidative stress effects of Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared with Indomethacin (ID) and Propranolol (PP) treatments.

Material and methods: Five groups of 10 rats treated i.p. were investigated: control group (healthy rats) injected with saline solution (0.9%), NTG-control group injected with NTG (1 mg/100 gbw, bw = body weight), and three groups with pretreatment applied 30 min previous to the formalin test (NTG + CC group: Curcumin (10 mg/100 gbw), NTG + PP group: Propranolol (100 μg/100 gbw), and NTG + ID group: Indomethacin (0.5 mg/100 gbw)). Formalin test was performed and number of flinches and shakes were counted. Several oxidative stress parameters were also assessed.

Results: The smallest values of malondialdehyde (MDA), nitric oxide (NOx), and total oxidative status (TOS) were observed on NTG + CC with significant differences as compared with the control group (p < 0.0001). The group pretreated with Curcumin proved significantly smaller number of flinches and shakes compared with both NTG + PP and NTG + ID.

Conclusion: Our study demonstrates a superior activity of Curcumin not only versus control, but also versus Propranolol and Indomethacin.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Number of flinches and shakes expressed as mean (the high of the column) and standard deviation (bars above the column) and different comparisons between groups for the two investigated phases.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gasparini C. F., Sutherland H. G., Griffiths L. R. Studies on the pathophysiology and genetic basis of migraine. Current Genomics. 2013;14(5):300–315. doi: 10.2174/13892029113149990007. - DOI - PMC - PubMed
    1. DosSantos M. F., Holanda-Afonso R. C., Lima R. L., DaSilva A. F., Moura-Neto V. The role of the blood–brain barrier in the development and treatment of migraine and other pain disorders. Frontiers in Cellular Neuroscience. 2014;8, article no. 302 doi: 10.3389/fncel.2014.00302. - DOI - PMC - PubMed
    1. Neri M., Frustaci A., Milic M., et al. A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine. Cephalalgia. 2015;35(10):931–937. doi: 10.1177/0333102414564888. - DOI - PubMed
    1. Buzzi M. G., Tassorelli C. Experimental models of migraine. Handbook of Clinical Neurology. 2010;97(C):109–123. doi: 10.1016/S0072-9752(10)97008-5. - DOI - PubMed
    1. De Tommaso M., Libro G., Guido M., et al. Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: A study of laser evoked potentials. Neuroscience Letters. 2004;363(3):272–275. doi: 10.1016/j.neulet.2004.04.029. - DOI - PubMed

MeSH terms

LinkOut - more resources