Predictive testing and clinical trials in Huntington's disease: An ethical analysis
- PMID: 29205501
- PMCID: PMC5854324
- DOI: 10.1002/mds.27247
Predictive testing and clinical trials in Huntington's disease: An ethical analysis
Keywords: Huntington's disease; clinical trial design; ethics; neurodegenerative diseases; predictive testing.
Conflict of interest statement
Cristina Sampaio has management functions within CHDI. Jamie Levey has management functions within CHDI and the European Huntington’s Disease Network. Robert Klitzman has no conflicts of interest to report.
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References
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- Levin BC, Richie KL, Jakupciak JP. Advances in Huntington's disease diagnostics: development of a standard reference material. Expert Rev Mol Diagn. 2006;6(4):587–596. - PubMed
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- MacLeod R, Tibben A, Frontali M, et al. Recommendations for the predictive genetic test in Huntington's disease. Clin Genet. 2013;83(3):221–231. - PubMed
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- Tabrizi SJ, Scahill RI, Owen G, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 2013;12(7):637–649. - PubMed
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