doi: 10.1002/chem.201705371.
Epub 2018 Jan 16.
Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation
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- PMID: 29205564
- DOI: 10.1002/chem.201705371
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Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation
Chemistry.
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Abstract
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.
Keywords: DNA-glycoconjugates; Pd catalysis; oligonucleotides; thioglycoconjugation; thiosaccharide.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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