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. 2018 Feb 6;24(8):1795-1800.
doi: 10.1002/chem.201705371. Epub 2018 Jan 16.

Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation

Nicolas Probst  1 , Rémy Lartia  2 , Océane Théry  2 , Mouâd Alami  1 , Eric Defrancq  2 , Samir Messaoudi  1
Affiliations

Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation

Nicolas Probst et al. Chemistry. .

Abstract

An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.

Keywords: DNA-glycoconjugates; Pd catalysis; oligonucleotides; thioglycoconjugation; thiosaccharide.

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