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Review
. 2017 Dec 5;17(12):2819.
doi: 10.3390/s17122819.

Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects

Shijie Deng  1 , Peng Wang  2 , Xinglong Yu  3
Affiliations
Review

Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects

Shijie Deng et al. Sensors (Basel). .

Abstract

Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry. This paper summarizes the fundamentals of phase-sensitive SPR sensing, reviews the available methods for phase interrogation of these sensors, and discusses the future prospects for and trends in the development of this technology.

Keywords: ellipsometry; heterodyne; interferometry; phase detection; surface plasmon resonance.

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Conflict of interest statement

The authors declare no conflict of interest. None of the material in the paper has been published or is under consideration for publication elsewhere.

Figures

Figure 1
Figure 1
Kretschmann configuration used for surface plasmon resonance (SPR) sensing (Adapted from [24]).
Figure 2
Figure 2
Heterodyne interferometry scheme used for SPR phase interrogation (Adapted from [35]).
Figure 3
Figure 3
Ellipsometry scheme for SPR phase interrogation (Adapted from [40]).
Figure 4
Figure 4
Shear interferometry scheme for SPR phase interrogation (Adapted from [48]).
Figure 5
Figure 5
Spatial phase modulation interferometry scheme for SPR phase interrogation (Adapted from [49]).
Figure 6
Figure 6
Temporal phase modulation interferometry scheme for SPR phase interrogation (Adapted from [60]).
See this image and copyright information in PMC

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