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Review
. 2017 Dec 5;22(12):2156.
doi: 10.3390/molecules22122156.

Bioactive Steroids and Saponins of the Genus Trillium

Shafiq Ur Rahman  1 , Muhammad Ismail  2 , Muhammad Khurram  3 , Irfan Ullah  4 , Fazle Rabbi  5 , Marcello Iriti  6
Affiliations
Review

Bioactive Steroids and Saponins of the Genus Trillium

Shafiq Ur Rahman et al. Molecules. .

Abstract

The species of the genus Trillium (Melanthiaceae alt. Trilliaceae) include perennial herbs with characteristic rhizomes mainly distributed in Asia and North America. Steroids and saponins are the main classes of phytochemicals present in these plants. This review summarizes and discusses the current knowledge on their chemistry, as well as the in vitro and in vivo studies carried out on the extracts, fractions and isolated pure compounds from the different species belonging to this genus, focusing on core biological properties, i.e., cytotoxic, antifungal and anti-inflammatory activities.

Keywords: analgesic activity; anti-inflammatory activity; antifungal activity; bioactive phytochemicals; cytotoxic activity.

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Conflict of interest statement

The authors declare no conflict of interest.

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