[Pharmacokinetics of cisplatin in long-term hemodialysis treatment]

Abstract

A 66-year-old woman with ovarian cancer which had metastasized was receiving chemotherapy with cisplatin and cyclophosphamide while undergoing haemodialysis for chronic renal failure. Cisplatin concentration in plasma was measured by flameless atomic absorption spectroscopy. After infusion of 40 mg cisplatin/m2 body-surface peak levels of 2.06 micrograms/ml and 2.29 micrograms/ml were obtained after the second and third treatment cycles, respectively. Terminal half-life was 14 days. Clearance value during haemodialysis was 470 ml/min. Seven treatment cycles were administered, up to doses of 60 mg/m2 cisplatin and 600 mg/m2 cyclophosphamide. Complete remission occurred after five treatment cycles. But the patient died 22 months after onset of treatment from an acute non-A, non-B hepatitis.