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. 2017 Dec 5;12(12):e0187992.
doi: 10.1371/journal.pone.0187992. eCollection 2017.

Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population

Hirotaka Shinomiya  1 , Hitomi Shinomiya  1 , Mie Kubo  1 , Yuki Saito  2 , Masafumi Yoshida  2 , Mizuo Ando  2 , Masanori Teshima  1 , Naoki Otsuki  1 , Naomi Kiyota  3 , Ryohei Sasaki  4 , Ken-Ichi Nibu  1
Affiliations

Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population

Hirotaka Shinomiya et al. PLoS One. .

Abstract

Background: Half of Japanese possess a polymorphism of aldehyde dehydrogenase 2(ALDH2), while few white individuals possess this mutation. The purpose of this study was to investigate the possibility of ALDH2 polymorphism as a prognostic factor for oropharyngeal cancer (OPC) among Japanese population.

Methods: We analyzed 82 Japanese patients with OPC treated between 2006 and 2011. The median observation period was 50 months. P16-staining and ALDH2 polymorphisms were investigated. To examine the frequencies of second primary pharyngeal and esophageal cancers (SPPEC),37 Japanese patients with OPC treated at Tokyo University Hospital were included for statistical analysis.

Results: Statistically significant differences were noted in OS among sex, age, N classification, and p16 (p = 0.045, 0.024, 0.020, 0.007, respectively). In addition, OS and DSS rates of the patients with heterozygous ALDH2 tended to be worse than those of the patients with homozygous ALDH2 (p = 0.21, 0.086, respectively). Of note, OS and DSS of the patients with p16-negative OPC and heterozygous ALDH2 was significant poorer than those of the patients with p16-positive OPC (p = 0.002, 0.006, respectively), while there was no significant difference in OS and DSS between patients with p16-positive OPC and patients with p16-negative OPC and homozygous ALDH2.

Conclusions: ALDH2 polymorphism might be a promising prognostic factor for Japanese patients with p16-negative OPC.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Survival rates according to HPV-status.
Survival curve with Kaplan-Meier estimates of (a) overall survival and (b) disease specific survival for patients with HPV-positive (dotted line) and HPV-negative OPC (solid line).
Fig 2
Fig 2. Survival rate according to ALDH2 polymorphism.
Survival curve with Kaplan-Meier estimates of (a) overall survival and (b) disease-specific survival for patients with homozygous (solid line) and with heterozygous ALDH2 (dotted line).
Fig 3
Fig 3. Risk-of-Death Categories according to p16-status and ALDH2 polymorphism.
Patients were divided into 3 risk-of-death categories according to p16-status and ALDH2 polymorphism.
Fig 4
Fig 4. Survival rates according to three risk-of-death categories.
Survival curves based on Kaplan-Meier estimates of (a) overall survival and (b) disease-specific survival for patients of the low-risk (small dotted line), the intermediate-risk (large dotted line) and the high-risk group (solid line).
Fig 5
Fig 5. Overall survival rates according to second primary pharyngeal and esophageal cancers.
Survival curves based on Kaplan-Meier estimates of overall survival for patients with SPPEC (red line) and without SPPEC (black line).
See this image and copyright information in PMC

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