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Comment
. 2017 Dec 4;43(5):547-548.
doi: 10.1016/j.devcel.2017.11.015.

Forcing Entry into the Nucleus

Alexis Lomakin  1 , Guilherme Nader  2 , Matthieu Piel  3
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Comment

Forcing Entry into the Nucleus

Alexis Lomakin et al. Dev Cell. .
Free article

Abstract

Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription factors. In a recent issue of Cell, Elosegui-Artola et al. (2017) show that nuclear deformation modulates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect gene transcription.

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  • Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.
    Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P. Elosegui-Artola A, et al. Cell. 2017 Nov 30;171(6):1397-1410.e14. doi: 10.1016/j.cell.2017.10.008. Epub 2017 Oct 26. Cell. 2017. PMID: 29107331

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