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Editorial
. 2017 Oct 9;8(53):90624-90625.
doi: 10.18632/oncotarget.21701. eCollection 2017 Oct 31.

Targeting autoreactive germinal centers to curb autoimmunity

Søren E Degn  1 , Cees E van der Poel  1 , Michael C Carroll  1
Affiliations
Editorial

Targeting autoreactive germinal centers to curb autoimmunity

Søren E Degn et al. Oncotarget. .
No abstract available

Keywords: B cells; autoimmunity; germinal genters; lymphocytes; systemic lupus erythematosus.

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Figures

Figure 1
Figure 1. Model of the autoreactive germinal center and the main mechanisms fueling the 'furnace of autoreactivity'
Follicular dendritic cells (FDCs) take up nucleolar debris, which in turn triggers endosomal TLR signaling, leading to interferon alpha production. Interferon alpha acts on protoautore active B cells, which upon antigen engagement take up nuclear components and present derived peptides to T follicular helper cells. T follicular helper cells stimulate the B cells through CD40L-CD40 interactions, among others, to enter or return to the dark zone of the germinal center. Resulting B cell centroblasts divide and hypermutate, then return to the light zone to probe FDCs for antigen, and the process is repeated. Autoantibodies produced by plasma cells derived from B cells in the germinal center facilitate immune complex loading, completing the vicious cycle of autoreactivity. Red arrows indicate the main driving signals and suggest possible points of intervention.
See this image and copyright information in PMC

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