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. 1989 Feb 15;45(2):209-11.
doi: 10.1007/BF01954881.

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

G R Pettit  1 , S B Singh, E Hamel, C M Lin, D S Alberts, D Garcia-Kendall
Affiliations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

G R Pettit et al. Experientia. .

Erratum in

  • Experientia 1989 Jul 15;45(7):680

Abstract

The African tree Combretum caffrum (Combretacae) has been found to contain a powerful inhibitor of tubulin polymerization (IC50 2-3 microM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50 approximately 0.003 microM and human colon cancer cell lines [(e.g. LoVo (ED50 = 0.005 microgram/ml), HT 29 (ED50 0.02 microgram/ml, Colo 205 (ED50 = 0.07 microgram/ml), DLD-1 (ED50 = 0.005 microgram/ml) and HCT-15 (ED50 = 0.0009 microgram/ml] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.

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References

    1. J Nat Prod. 1987 Jan-Feb;50(1):119-31 - PubMed

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