doi: 10.1007/BF01954881.
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
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- PMID: 2920809
- DOI: 10.1007/BF01954881
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Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
Experientia.
.
Erratum in
- Experientia 1989 Jul 15;45(7):680
Abstract
The African tree Combretum caffrum (Combretacae) has been found to contain a powerful inhibitor of tubulin polymerization (IC50 2-3 microM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50 approximately 0.003 microM and human colon cancer cell lines [(e.g. LoVo (ED50 = 0.005 microgram/ml), HT 29 (ED50 0.02 microgram/ml, Colo 205 (ED50 = 0.07 microgram/ml), DLD-1 (ED50 = 0.005 microgram/ml) and HCT-15 (ED50 = 0.0009 microgram/ml] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.
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References
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- J Nat Prod. 1987 Jan-Feb;50(1):119-31 - PubMed
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