Intestinal organoid culture model is a valuable system to study epithelial barrier function in IBD

Pan Xu^{1

2}, Heike Becker^{1

2}, Montserrat Elizalde^{1

2}, Ad Masclee^{1

2}, Daisy Jonkers^{1

2}

Affiliations

¹ Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
² School for Nutrition, Toxicology and Metabolism of Maastricht University Medical center, Maastricht, The Netherlands.

Comment

Pan Xu et al. Gut. 2018 Oct.

. 2018 Oct;67(10):1905-1906.

doi: 10.1136/gutjnl-2017-315685. Epub 2017 Dec 5.

Pan Xu^{1

2}, Heike Becker^{1

2}, Montserrat Elizalde^{1

2}, Ad Masclee^{1

2}, Daisy Jonkers^{1

2}

¹ Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
² School for Nutrition, Toxicology and Metabolism of Maastricht University Medical center, Maastricht, The Netherlands.

No abstract available

Keywords: inflammatory bowel disease; intestinal barrier function.

Conflict of interest statement

Competing interests: None declared.

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis.
Dotti I, Mora-Buch R, Ferrer-Picón E, Planell N, Jung P, Masamunt MC, Leal RF, Martín de Carpi J, Llach J, Ordás I, Batlle E, Panés J, Salas A. Dotti I, et al. Gut. 2017 Dec;66(12):2069-2079. doi: 10.1136/gutjnl-2016-312609. Epub 2016 Nov 1. Gut. 2017. PMID: 27803115 Free PMC article.