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Meta-Analysis
. 2018 Jan 10;38(1):BSR20171342.
doi: 10.1042/BSR20171342. Print 2018 Feb 28.

miR-146a C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies

Dezhong Sun  1 , Xiaoyan Zhang  2 , Xiaolei Zhang  3
Affiliations
Meta-Analysis

miR-146a C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies

Dezhong Sun et al. Biosci Rep. .

Abstract

Several studies have evaluated the association of miR-146a C/G with head and neck cancer (HNC) susceptibility, and overall cancer risk, but with inconclusive outcomes. To drive a more precise estimation, we carried out this meta-analysis. The literature was searched from MEDLINE (mainly PubMed), Embase, the Cochrane Library, and Google Scholar databases to identify eligible studies. A total of 89 studies were included. The results showed that miR-146a C/G was significantly associated with increased HNC risk in dominant model (I2 =15.6%, Pheterogeneity=0.282, odds ratio (OR) =1.088, 95% confidence interval (CI) =1.002-1.182, P=0.044). However, no cancer risk was detected under all genetic models. By further stratified analysis, we found that rs4919510 mutation contributed to the risk of HNC amongst Asians under homozygote model (I2 =0, Pheterogeneity=0.541, OR =1.189, 95% CI =1.025-1.378, P=0.022), and dominant model (I2 =0, Pheterogeneity=0.959, OR =1.155, 95% CI =1.016-1.312, P=0.028). Simultaneously, in the stratified analysis by source of controls, a significantly increased cancer risk amongst population-based studies was found under homozygote model, dominant model, recessive model, and allele comparison model. However, no significant association was found in the stratified analysis by ethnicity and source of control. The results indicated that miR-146a C/G polymorphism may contribute to the increased HNC susceptibility and could be a promising target to forecast cancer risk for clinical practice. However, no significant association was found in subgroup analysis by ethnicity and source of control. To further confirm these results, well-designed large-scale case-control studies are needed in the future.

Keywords: cancer risk; head and neck cancer; meta-analysis; miR-146a C/G; polymorphism.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. The process of literature research
Figure 2
Figure 2. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under homozygote model)
Figure 3
Figure 3. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under heterozygote model)
Figure 4
Figure 4. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under recessive model)
Figure 5
Figure 5. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under allele comparison model)
Figure 6
Figure 6. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under dominant model)
Figure 7
Figure 7. Forest plot of the association between miR-146a rs2910164 polymorphism and overall risk (under homozygote model)
Figure 8
Figure 8. Forest plot of the association between miR-146a rs2910164 polymorphism and overall cancer risk (under heterozygote model)
Figure 9
Figure 9. Forest plot of the association between miR-146a rs2910164 polymorphism and HNC risk (under dominant model)
Figure 10
Figure 10. Forest plot of the association between miR-146a rs2910164 polymorphism and overall cancer risk (under recessive model)
Figure 11
Figure 11. Forest plot of the association between miR-146a rs2910164 polymorphism and overall cancer risk (under allele comparison model)
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